Thesis recently launched!

Launch YC: δ Thesis

"Building the frontier of AI driven discovery."

Thesis is an applied research lab building the frontier of AI driven discovery. They're making it possible for researchers anywhere to discover the next Transformer or invent the next AlphaFold.

Founded by Sergio Charles & Luigi Charles

Team

Sergio and Luigi are brothers. In 2021, they published papers on how AI could one day invent its own algorithms. With the advent of modern methods in AI, that dream is now possible.

Sergio worked on AI R&D at Google X, Nvidia, and Stanford’s AI Lab (SAIL). He has published work at NeurIPS and ICML, and has worked with Chelsea Finn and Andrew Ng.

Luigi built Sphere, a fintech company that processes billions of dollars every year in global cross-border payments. Sphere was recently valued at $250 M+ in its Series A round.

Mission

The founders' mission is to make state-of-the-art AI discovery 10x faster and 10x cheaper. The big labs are racing to get there, but their need to productize and turn a profit has already weighed them down. Thesis embraces rapid experimentation and novel fundamental research. The founders' singular focus, outcome-driven mindset, and early results give them confidence that Thesis can get there first.

Results

Thesis is state-of-the-art on OpenAI’s Machine Learning Engineering benchmark (MLE-Bench).

MLE-Bench tests how well AI systems can train ML models autonomously, a first step toward self-improving systems. Thesis achieved this result in the record time of 1 month and with only $10k in compute. Agents will get you far, but not far enough. The founders' methods mix old school with new, and have already outperformed teams of researchers at Microsoft, Google, Meta, and Baidu.

Image Credit: Thesis

10 Year Vision

The holy grail of AI is building self-improving systems that, guided by human creativity, enable breakthroughs and new paradigms achieving state-of-the-art results under resource constraints.

In the limit, the Thesis engine will expand beyond ML to every domain of science, from computational biology, to theoretical mathematics and physics. Thesis will autonomously discover new knowledge and become the driving force behind humanity’s scientific progress.

Learn More

🌐 Visit thesislabs.ai to learn more.
🤝 The founders' collaborate with leading institutions, startups, and independent researchers around the world. If you’re interested in what they’re building, please get in touch via email here.
👣 Follow Thesis on LinkedIn & X.

Posted 
December 2, 2025
 in 
Launch
 category
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